US Route 250 South from Huttonsville, West Virginia, to Staunton, Virginia. This route gives the Tail of the Dragon a run for its money. One could get dizzy from all the switchbacks.
http://maps.google.com/maps?f=d&source=s_d&saddr=huttonsville+WV&daddr=Staunton,+Virginia&geocode=&hl=en&mra=pe&mrcr=0&rtol=0&sll=38.410725,-79.491168&sspn=1.22025,1.897888&ie=UTF8&ll=38.766933,-78.920288&spn=2.428333,3.795776&z=8
U.S. Route 52 from Bluefield, West Virginia, to Williamson, West Virginia.
http://maps.google.com/maps?f=d&source=s_d&saddr=South+St&daddr=US-52+to:US-52%2FWV-80+to:US-52+to:37.676484,-82.282448&geocode=FWSEOAIdPq0o-w%3BFesxOwIdqTcj-w%3BFVLwPQIdHNQe-w%3BFZZ8PgIdEcwc-w%3B&hl=en&mra=mi&mrcr=3&mrsp=4&sz=13&rtol=0,1,2,3&
sll=37.679201,-82.25275&sspn=0.077033,0.118618&ie=UTF8&ll=37.267223,-81.172142&spn=0.154917,0.237236&z=12
In North Carolina, from Ashville north to Hot Springs on Route 63 and Route 209. After riding the twisties you can get home style Southern meals at the Hot Springs restaurant.
http://maps.google.com/maps?f=d&source=s_d&saddr=Asheville,+North+Carolina&daddr=NC-63+to:35.892318,-82.82979&geocode=%3BFQyFIQId-IQP-w%3B&hl=en&mra=dme&mrcr=1&mrsp=2&sz=14&rtol=0,1&sll=35.88147,-82.826443&sspn=0.039431,0.059309&ie=UTF8&
ll=35.755986,-82.714005&spn=0.315943,0.474472&z=11